(Philadelphia – July 17, 2006) -– More than half of human cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical role played by the normal p53 protein in defending against ...

UNIVERISTY PARK, Pa. — The tumor suppressor protein p53, known as "the guardian of the genome," protects the body’s DNA from daily stress or long-term damage by triggering the cells to make repairs or ...

A Ca 2+ dependent conformational change in dimeric S100B(ββ) is required for it to bind p53 and inhibit phosphorylation of this tumor suppressor in its C-terminal negative regulatory domain. A peptide ...

Since its discovery by Arnold Levine in 1979, the tumor protein p53 has transformed the field of cancer research. p53 signaling plays a key role in regulating the cell cycle, maintaining genome ...

Researchers at the Wistar Institute successfully determined, and reported in the July 21 issue of the Journal of Biological Chemistry, the three-dimensional structure of the p53 protein bound as a ...